Phenotypes Associated with This Genotype

Genotype
MGI:6196047

• Allelic Composition: Tg(CAG-Alk*F1174L,-luc)60Jhsc/0; Tg(Dbh-icre)1Gsc/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased neuroblastoma incidence ( J:186696 )

• all mice develop neuroblastomas within 48 days of age

• tumor incidence is higher and time to tumor formation is shorter than in mice expressing only Tg(Th-MYCN)41Waw

• tumors show a reduction in the number of genomic aberrations compared to tumors in mice expressing only Tg(Th-MYCN)41Waw or Tg(CAG-Alk*F1174L,-luc)60Jhsc

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show some regression of tumors

nervous system

increased neuroblastoma incidence ( J:186696 )

• all mice develop neuroblastomas within 48 days of age

• tumor incidence is higher and time to tumor formation is shorter than in mice expressing only Tg(Th-MYCN)41Waw

• tumors show a reduction in the number of genomic aberrations compared to tumors in mice expressing only Tg(Th-MYCN)41Waw or Tg(CAG-Alk*F1174L,-luc)60Jhsc

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show some regression of tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:186696