Phenotypes Associated with This Genotype

Genotype
MGI:6196129

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺; Tg(Dbh-icre)1Gsc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased neuroblastoma incidence ( J:222527 )

• mice develop abdominal tumors with an incidence of 76%

• tumor onset occurs between 26-337 days of age, with a mean age of 79.6 days

• tumors arise from the superior cervical ganglion, the adrenals, or the celiac ganglion

• histology indicates small round cell tumor with cells harboring neurosecretory vesicles and express markers indicative of neuroblastoma

• neuroblastomas are characterized by genomic aberrations syntenic to human neuroblastomas

endocrine/exocrine glands

adrenal medulla hyperplasia ( J:222527 )

• hyperplastic cells are present in the adrenal medulla of some adrenal glands in 0-day old pups and most 14 and 28 day old mice

• at 28 days of age, the adrenal medulla has an atypical, nodal tissue architecture

nervous system

increased neuroblastoma incidence ( J:222527 )

• mice develop abdominal tumors with an incidence of 76%

• tumor onset occurs between 26-337 days of age, with a mean age of 79.6 days

• tumors arise from the superior cervical ganglion, the adrenals, or the celiac ganglion

• histology indicates small round cell tumor with cells harboring neurosecretory vesicles and express markers indicative of neuroblastoma

• neuroblastomas are characterized by genomic aberrations syntenic to human neuroblastomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:222527