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Phenotypes Associated with This Genotype
Genotype
MGI:6196218
cx5
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Tg(H2-Dd)28Bee/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
Klra1tm1.1Wyok mutation (0 available); any Klra1 mutation (17 available)
Tg(H2-Dd)28Bee mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:252851 )
N
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
abnormal NK cell physiology ( J:252851 )
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)

immune system
abnormal NK cell physiology ( J:252851 )
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory