Phenotypes Associated with This Genotype

Genotype
MGI:6196613

ot4

• Allelic Composition: Abcd1^tm1Kan/Y
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6J * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased fatty acids level ( J:257393 )

♂ • mice exhibit very-long-chain fatty acid accumulation in different lipid classes and acylcarnitines

♂ • total C26:0 levels are increased 8-fold in brain, 4-fold in adrenals, 1.5-fold in testes, 4.5-fold in lung, 2.5-fold in liver, and 3.5-fold in kidney

♂ • 1-hexacosanoyl-sn-glycero-3-phosophocholine (C26:0-lysoPC) levels are increased 4-fold in the brain, 6-fold in the spinal cord, and 6-fold in the blood

♂ • C26:0-carnitine levels are increased 10-fold in brain, 9-fold in spinal cord, and 6-fold in the blood

♂ • however, total plasma C26:0 is not increased