Analysis Tools
growth/size/body
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• mice are runted prior to weaning
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• mice exhibit lower body weights throughout life
• mice treated with an alpha IL-1R blocking antibody show weight gain
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• sick mice exhibit enlarged spleen
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digestive/alimentary system
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• pronounced neutrophilia is seen in the duodenums, with neutrophilic infiltration of the submucosa and lamina propria that extends into the underlying muscularis externa
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hematopoietic system
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• sick mice exhibit enlarged spleen
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• pronounced neutrophilia is seen in the joints, duodenums, and kidney glomeruli
• increase in neutrophils in the peripheral blood of sick mice compared to healthy littermates
• increase in levels of neutrophils in spleen, and in peripheral and mesenteric lymph nodes
• mice treated with an alpha IL-1R blocking antibody show decreased levels of neutrophils in both the spleen and lymph nodes
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• slight increase of T cells in the spleen, however there are no changes in T cells in the lymph nodes
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• decrease in blood lymphocytes
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• B cell numbers are modestly decreased in the lymph nodes
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• increase in monocytes in the peripheral blood of the sick mice compared to healthy littermates
• increase in levels of monocytes in spleen, and in peripheral and mesenteric lymph nodes
• mice treated with an alpha IL-1R blocking antibody show decreased levels of monocytes in both the spleen and lymph nodes
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homeostasis/metabolism
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• serum levels of cytokines and chemokines (IL-1 alpha, IL-1 beta, IFN-gamma, IL-6, MCP-1) are elevated
• mice treated with an alpha IL-1R blocking antibody show decreased IL-1bbeta, MCP-1, and TNF levels, however, levels of IL-18 are unchanged
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• mice develop severe limb swelling, most noticeably in the tibiotarsal (heel) joint
• tibiotarsal joint swelling is 100% penetrant, although age of onset varies, beginning as early as 4 weeks or as late as 10 weeks of age
• substantial neutrophilic infiltration with slight to severe bone and cartilage erosion is seen in the tibiotarsal joint
• mice treated with an alpha IL-1R blocking antibody show decreased tibiotarsal joint swelling
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immune system
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• sick mice exhibit enlarged spleen
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• pronounced neutrophilia is seen in the joints, duodenums, and kidney glomeruli
• increase in neutrophils in the peripheral blood of sick mice compared to healthy littermates
• increase in levels of neutrophils in spleen, and in peripheral and mesenteric lymph nodes
• mice treated with an alpha IL-1R blocking antibody show decreased levels of neutrophils in both the spleen and lymph nodes
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• slight increase of T cells in the spleen, however there are no changes in T cells in the lymph nodes
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• decrease in blood lymphocytes
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• B cell numbers are modestly decreased in the lymph nodes
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• increase in monocytes in the peripheral blood of the sick mice compared to healthy littermates
• increase in levels of monocytes in spleen, and in peripheral and mesenteric lymph nodes
• mice treated with an alpha IL-1R blocking antibody show decreased levels of monocytes in both the spleen and lymph nodes
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• serum levels of cytokines and chemokines (IL-1 alpha, IL-1 beta, IFN-gamma, IL-6, MCP-1) are elevated
• mice treated with an alpha IL-1R blocking antibody show decreased IL-1bbeta, MCP-1, and TNF levels, however, levels of IL-18 are unchanged
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• sick mice exhibit enlarged lymph nodes
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• mice exhibit systemic inflammation, with nearly all tissues showing neutrophilic infiltration
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• pronounced neutrophilia is seen in the duodenums, with neutrophilic infiltration of the submucosa and lamina propria that extends into the underlying muscularis externa
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• substantial neutrophilic infiltration with slight to severe bone and cartilage erosion is seen in the tibiotarsal joint
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• mice show varying degrees of kidney damage, with some mice having fibrin and neutrophil accumulation within the glomeruli indicating necrotizing glomerulonephritis, while others have some glomeruli with only thickened membranes
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renal/urinary system
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• some mice exhibit glomeruli with only thickened membranes
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• mice show varying degrees of kidney damage, with some mice having fibrin and neutrophil accumulation within the glomeruli indicating necrotizing glomerulonephritis, while others have some glomeruli with only thickened membranes
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skeleton
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• mice develop severe limb swelling, most noticeably in the tibiotarsal (heel) joint
• tibiotarsal joint swelling is 100% penetrant, although age of onset varies, beginning as early as 4 weeks or as late as 10 weeks of age
• substantial neutrophilic infiltration with slight to severe bone and cartilage erosion is seen in the tibiotarsal joint
• mice treated with an alpha IL-1R blocking antibody show decreased tibiotarsal joint swelling
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• substantial neutrophilic infiltration with slight to severe bone and cartilage erosion is seen in the tibiotarsal joint
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary immunodeficiency disease | DOID:612 |
OMIM:242850 OMIM:PS300755 |
J:260047 | |
