behavior/neurological
N |
• no defects in memory or movement
|
• spend more time in the closed arm of an elevated plus maze
• in an open field test mice spend less time in the inside area and have fewer center entries
• spend less time in the light compartment and make fewer light-dark transitions in a light-dark box test
• bury more marbles in a marble burying assay
• treatment with imipramine attenuates anxiety-like behaviors
|
• increased grooming time and number of grooming bouts
• treatment with imipramine attenuates excessive self-grooming
|
nervous system
integument
• hair loss that is aggravated with age with 15% and 30% of mice showing hair loss at 4 and 6 months of age
|
growth/size/body
• from P1 to 2 months of age
|
• delayed growth from P1 to 2 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
generalized anxiety disorder | DOID:14320 | J:262219 |