Phenotypes Associated with This Genotype

Genotype
MGI:6198760

hm2

• Allelic Composition: Ppp2r5a^{Gt(IST13127C10)Tigm}/Ppp2r5a^{Gt(IST13127C10)Tigm}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:254808 )

• earlier appearance of skin papillomas after DMBA/TPA treatment: 53.2 days after TPA treatment start vs 75.6 in wild-type

• total number of papillomas and number of papillomas converted to squamous cell carcinoma (SCC) after 20 weeks of TPA treatment

neoplasm

increased incidence of tumors by chemical induction ( J:254808 )

• earlier appearance of skin papillomas after DMBA/TPA treatment: 53.2 days after TPA treatment start vs 75.6 in wild-type

• total number of papillomas and number of papillomas converted to squamous cell carcinoma (SCC) after 20 weeks of TPA treatment