Phenotypes for Pten Tg(CAG-MYC,-GFP*)#Rugg Tg(Pbsn-cre)4Prb MGI:6198766 MGI Mouse

mortality/aging

premature death ( J:261540 )

• mice show decreased overall survival, with a mean life span of 75 weeks

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:261540 )

• mice develop prostatic adenocarcinoma by 10 weeks of age

• mice with developed tumors treated with a small-molecule inhibitor of P-eIF2alpha activity, ISRIB, show tumor regression within 3 weeks of treatment, with no signs of toxicity

increased prostate intraepithelial neoplasia incidence ( J:261540 )

• mice show enlargement of prostate growth by 6 weeks of age and accelerated development of high-grade prostatic intraepithelial neoplasia compared to single conditional Pten^tm1Hwu mutants

neoplasm

increased prostate gland adenocarcinoma incidence ( J:261540 )

• mice develop prostatic adenocarcinoma by 10 weeks of age

• mice with developed tumors treated with a small-molecule inhibitor of P-eIF2alpha activity, ISRIB, show tumor regression within 3 weeks of treatment, with no signs of toxicity

increased prostate intraepithelial neoplasia incidence ( J:261540 )

• mice show enlargement of prostate growth by 6 weeks of age and accelerated development of high-grade prostatic intraepithelial neoplasia compared to single conditional Pten^tm1Hwu mutants

reproductive system

increased prostate gland adenocarcinoma incidence ( J:261540 )

• mice develop prostatic adenocarcinoma by 10 weeks of age

• mice with developed tumors treated with a small-molecule inhibitor of P-eIF2alpha activity, ISRIB, show tumor regression within 3 weeks of treatment, with no signs of toxicity

increased prostate intraepithelial neoplasia incidence ( J:261540 )

• mice show enlargement of prostate growth by 6 weeks of age and accelerated development of high-grade prostatic intraepithelial neoplasia compared to single conditional Pten^tm1Hwu mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:261540

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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