Phenotypes Associated with This Genotype

Genotype
MGI:6199144

• Allelic Composition: Tg(BAC144D14)5D3Masu/0
• Genetic Background: B6.Cg-Tg(BAC144D14)5D3Masu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal sucrose solution preference ( J:239325 )

• lick cluster size analysis to measure perceived palatability shows that mice have a smaller average lick cluster sizes while total number of licks and total number of bouts are similar to wild-type and no difference in overall consumption of the solution or inter lick interval are seen, indicating that mutants perceive a lower palatability of a sucrose solution

decreased locomotor activity ( J:239325 )

• mice are hypoactive, making nearly half as many runs in any given session as controls

• hypoactivity is not related to impaired motoric function as mice exhibit normal behavior on the rotarod

• however, emotional reactivity and anxiety are not altered, with mice showing normal behavior in the elevated plus maze test and the open field test

hearing/vestibular/ear

impaired hearing ( J:239325 )

• general hearing impairment

nervous system

abnormal hypothalamus morphology ( J:239325 )

• increase in tyrosine hydroxylase+ cells in the periventricular hypothalamus

reduced sensorimotor gating ( J:239325 )

• impaired sensorimotor gating response

decreased prepulse inhibition ( J:239325 )

• prepulse inhibition of the acoustic startle response is attenuated by almost half, with further inhibition with increasing prepulse

• however, no difference in acoustic startle response at 105 dB

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Silver-Russell syndrome		DOID:14681	OMIM:180860	J:239325