Analysis Tools
reproductive system
 N |
• male fertility is normal
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• significant increase in the number of MII oocytes with abnormal spindle morphology, misalignment of chromosomes on the spindle and numerous cytoplasmic asters
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• oocyte growth is impaired
• increase in the percentage of oocytes released at stages before MII, 45% compared to 26% in wild-type controls
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• following pregnant mare serum gonadotropin ovarian stimulation, germinal vesicle oocytes are smaller in diameter compared to similarly treated wild-type controls
• however, the number of oocytes produced by stimulation is similar to controls
• unlike human patients, stimulated mice produce MII stage oocytes but these are also smaller in diameter compared to controls
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• oocyte meiotic maturation is impaired
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• oocytes apparently arrested at MI display misaligned chromosomes and abundant cytoplasmic asters
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• significant increase in the number of MII oocytes with abnormal spindle morphology, misalignment of chromosomes on the spindle and numerous cytoplasmic asters
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• increase in the number of primordial oocytes at P26 but not at P12 compared to wild-type controls
• numbers of primary and secondary follicles are similar at P12 and P26
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• severe reduction with both total number of pups and litters per month reduced over a 6 month period when crossed to wild-type males
• fertilized zygotes show numerous defects, including delayed pronucleus formation, absence of sperm DNA decondensation, and/or polyspermy
• only 27.2% +/- 5.1 of 2-cell embryos reach the blastocyst stage compared to 87.1% +/- 5.6% for wild-type controls
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• average litter size is 2.3 +/- 0.4 compared to 7.3 +/- 0.8 for wild-type controls when both are crossed to wild-type males
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polyspermy
(
J:264835
)
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• fertilized zygotes show numerous defects, including polyspermy
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• decrease in the percentage of eggs reaching the 2-cell stage following IVF to 36.4% +/- 6.4%, estimated to be a 65% success rate for MII stage oocytes compared to 90% for wild-type controls
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cellular
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• significant increase in the number of MII oocytes with abnormal spindle morphology, misalignment of chromosomes on the spindle and numerous cytoplasmic asters
|
|
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• oocyte growth is impaired
• increase in the percentage of oocytes released at stages before MII, 45% compared to 26% in wild-type controls
|
|
|
• following pregnant mare serum gonadotropin ovarian stimulation, germinal vesicle oocytes are smaller in diameter compared to similarly treated wild-type controls
• however, the number of oocytes produced by stimulation is similar to controls
• unlike human patients, stimulated mice produce MII stage oocytes but these are also smaller in diameter compared to controls
|
|
|
• oocyte meiotic maturation is impaired
|
|
|
• oocytes apparently arrested at MI display misaligned chromosomes and abundant cytoplasmic asters
|
|
|
• significant increase in the number of MII oocytes with abnormal spindle morphology, misalignment of chromosomes on the spindle and numerous cytoplasmic asters
|
endocrine/exocrine glands
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• increase in the number of primordial oocytes at P26 but not at P12 compared to wild-type controls
• numbers of primary and secondary follicles are similar at P12 and P26
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ovarian disease | DOID:1100 | J:264835 | ||
