Analysis Tools
embryo
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• melanoblasts in E14.5 skin explants show significantly reduced cell migration speed and euclidean distance travelled relative to wild-type controls
• ~30% of melanoblasts migrate with a speed slower than 0.5 um/minute versus fewer than 10% of melanoblasts in wild-type explants
• however, directionality (the ratio between the euclidean distance and total distance travelled) is normal
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• melanoblasts in E14.5 live skin explants are slightly smaller than wild type
• the rate of pseudopod generation in melanoblasts is modestly reduced but the lifetime of pseudopods is increased
• melanoblasts extend thinner protrusions with a smaller cross-sectional width than wild type controls
• thinner pseudopodia are less dynamic (longer-lived) leading to slower melanoblast migration
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cellular
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• melanoblasts in E14.5 skin explants show significantly reduced cell migration speed and euclidean distance travelled relative to wild-type controls
• ~30% of melanoblasts migrate with a speed slower than 0.5 um/minute versus fewer than 10% of melanoblasts in wild-type explants
• however, directionality (the ratio between the euclidean distance and total distance travelled) is normal
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nervous system
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• melanoblasts in E14.5 live skin explants are slightly smaller than wild type
• the rate of pseudopod generation in melanoblasts is modestly reduced but the lifetime of pseudopods is increased
• melanoblasts extend thinner protrusions with a smaller cross-sectional width than wild type controls
• thinner pseudopodia are less dynamic (longer-lived) leading to slower melanoblast migration
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