Phenotypes Associated with This Genotype

Genotype
MGI:6220632

cn9

• Allelic Composition: Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi; Tg(Tyr-cre)1Lru/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

reduced hair shaft melanin granule number ( J:211299 )

♂ • at 4-6 months of age, the melanin content of the dorsal and ventral hair shafts is reduced by 93% and 91%, respectively

♂ • light microscopy confirmed the loss of melanin pigment from the hair shafts; however, hair with mixed pigmentation are also observed

hypopigmentation ( J:211299 )

♂ • mice show severe congenital loss of hair pigmentation relative to control mice

♂ • loss of hair pigmentation is evident from the first hair cycle and continues through adulthood

♂ • however, eyes remain pigmented

integument

reduced hair shaft melanin granule number ( J:211299 )

♂ • at 4-6 months of age, the melanin content of the dorsal and ventral hair shafts is reduced by 93% and 91%, respectively

♂ • light microscopy confirmed the loss of melanin pigment from the hair shafts; however, hair with mixed pigmentation are also observed