Phenotypes Associated with This Genotype

Genotype
MGI:6220867

cn19

• Allelic Composition: Chek1^tm1Jmr/Chek1^tm1Jmr; Tg(Tyr-cre)1Lru/Y
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal hair follicle melanocyte morphology ( J:265850 )

♂ • no DCT-expressing melanocytes are observed in the hair follicles, unlike in control mice

absent coat pigmentation ( J:265850 )

♂ • adult male mice are completely devoid of coat pigmentation, unlike control mice

abnormal epidermal melanocyte morphology ( J:265850 )

♂ • male mice show complete lack of epidermal melanocytes

decreased melanocyte number ( J:265850 )

♂ • adult males show a marked reduction or absence of neural crest-derived melanocytes in the eyes, unlike control mice

♂ • however, males retain normal eye pigmentation in the retinal pigmented epithelium (RPE) due to inefficient transgene expression in the RPE

integument

abnormal hair follicle melanocyte morphology ( J:265850 )

♂ • no DCT-expressing melanocytes are observed in the hair follicles, unlike in control mice

absent coat pigmentation ( J:265850 )

♂ • adult male mice are completely devoid of coat pigmentation, unlike control mice

abnormal epidermal melanocyte morphology ( J:265850 )

♂ • male mice show complete lack of epidermal melanocytes