Phenotypes Associated with This Genotype

Genotype
MGI:6220868

cn16

• Allelic Composition: Chek1^tm1Jmr/Chek1^tm1Jmr; Tg(Dct-lacZ)A12Jkn/0; Tg(Tyr-cre)1Lru/Y
• Genetic Background: involves: C57BL/6 * CBA * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal melanoblast morphology ( J:265850 )

♂ • significantly fewer beta-gal+ melanoblasts are noted in the head and trunk regions at E12.5, and by E13.5, melanoblasts are completely lost even from the pinna, vibrissae, and around the eyes

♂ • many cleaved caspase 3+ melanoblasts are observed in the head and trunk regions, unlike in control embryos, suggesting increased melanoblast apoptosis

♂ • however, the number and distribution of beta-gal+ melanoblasts is normal at E10.5 and E11.5

nervous system

abnormal melanoblast morphology ( J:265850 )

♂ • significantly fewer beta-gal+ melanoblasts are noted in the head and trunk regions at E12.5, and by E13.5, melanoblasts are completely lost even from the pinna, vibrissae, and around the eyes

♂ • many cleaved caspase 3+ melanoblasts are observed in the head and trunk regions, unlike in control embryos, suggesting increased melanoblast apoptosis

♂ • however, the number and distribution of beta-gal+ melanoblasts is normal at E10.5 and E11.5

cellular

abnormal DNA replication ( J:265850 )

♂ • many gamma-H2AX+ melanoblasts are noted in the head and trunk regions, unlike in control embryos, suggesting that aberrant DNA replication leads to spontaneous DNA damage and ultimately cell death

homeostasis/metabolism

abnormal DNA replication ( J:265850 )

♂ • many gamma-H2AX+ melanoblasts are noted in the head and trunk regions, unlike in control embryos, suggesting that aberrant DNA replication leads to spontaneous DNA damage and ultimately cell death