Analysis Tools
pigmentation
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• mice exhibit premature gray hair after the first hair cycle
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• during the first hair cycle (P0-P28), P10 ventral hairs are essentially devoid of pigment, whereas hairs from dorsal skin are much less pigmented than those in control mice; however, white dorsal fur is observed by P45
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• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack DCT+ melanocytes, corresponding to subsequent white dorsal fur seen at P45
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• at P4, dorsal skin shows small amounts of residual hair follicle melanin; residual dorsal melanocytes (DCT+) continue to express YY1, indicating incomplete Cre-mediated deletion
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• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack melanin pigment
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• at P4, mice show profoundly lighter skin pigmentation relative to control mice
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• mice exhibit complete loss of hair follicle melanocytes after the first hair cycle
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integument
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• mice exhibit premature gray hair after the first hair cycle
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• during the first hair cycle (P0-P28), P10 ventral hairs are essentially devoid of pigment, whereas hairs from dorsal skin are much less pigmented than those in control mice; however, white dorsal fur is observed by P45
|
|
|
• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack DCT+ melanocytes, corresponding to subsequent white dorsal fur seen at P45
|
|
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• at P4, dorsal skin shows small amounts of residual hair follicle melanin; residual dorsal melanocytes (DCT+) continue to express YY1, indicating incomplete Cre-mediated deletion
|
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• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack melanin pigment
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• at P4, mice show profoundly lighter skin pigmentation relative to control mice
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