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Phenotypes Associated with This Genotype
Genotype
MGI:6226060
cn10
Allelic
Composition
Yy1tm2.1Yshi/Yy1tm2.1Yshi
Tg(Dct-lacZ)A12Jkn/0
Tg(Tyr-cre)1Lru/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dct-lacZ)A12Jkn mutation (5 available)
Tg(Tyr-cre)1Lru mutation (1 available)
Yy1tm2.1Yshi mutation (0 available); any Yy1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Absence of melanocytes or pigment in hair follicles of Yy1tm2.1Yshi/Yy1tm2.1Yshi Tg(Tyr-cre)1Lru/Y Tg(Dct-lacZ)A12Jkn/0 mice at the anagen phase of the second hair cycle

pigmentation
• mice show absence of differentiated melanocytes in hair follicles at the anagen phase of the second hair cycle (P38)
• mice show absence of pigment in hair follicles at the anagen phase of the second hair cycle (P38)
• absence of differentiated melanocytes in hair follicles at P38

integument
• mice show absence of differentiated melanocytes in hair follicles at the anagen phase of the second hair cycle (P38)
• mice show absence of pigment in hair follicles at the anagen phase of the second hair cycle (P38)

embryo
• absence of Dct-LacZ+ melanocyte stem cells (melanoblasts) in hair follicles at P38

nervous system
• absence of Dct-LacZ+ melanocyte stem cells (melanoblasts) in hair follicles at P38


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory