Phenotypes Associated with This Genotype

Genotype
MGI:6256432

• Allelic Composition: Nlrp3^tm1Bhk/Nlrp3^tm1Bhk
• Genetic Background: B6.129S6-Nlrp3^tm1Bhk/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

white adipose tissue inflammation ( J:256504 )

• mice fed a Western diet exhibit a higher degree of inflammation in epididymal fat than controls on the same diet

• Western diet-fed mice treated with antibiotic show decreased adipose tissue inflammation

decreased interleukin-1 beta secretion ( J:253629 )

• cultured cochleae stimulated with LPS pulsed with ATP do not secrete IL-1beta like in wild-type cochlea

adipose tissue

increased body fat mass ( J:256504 )

• mice fed a Western diet exhibit a greater increase in body fat mass than controls on the same diet

white adipose tissue inflammation ( J:256504 )

• mice fed a Western diet exhibit a higher degree of inflammation in epididymal fat than controls on the same diet

• Western diet-fed mice treated with antibiotic show decreased adipose tissue inflammation

cellular

oxidative stress ( J:256504 )

• mice fed a Western diet exhibit increased ROS production, indicating increased oxidative stress

digestive/alimentary system

abnormal digestive system physiology ( J:256504 )

• mice fed a Western diet show a higher increase in bacterial growth of mesenteric lymph node cultures, indicating increased bacterial translocation through the gut barrier and impaired gut barrier

• Western diet-fed mice treated with antibiotic show lowered bacterial growth in cultured lymph nodes, indicating reduced bacterial translocation

abnormal gut flora balance ( J:256504 )

• mice fed a Western diet show a greater gut microbiota dysbiosis than controls on the same diet

growth/size/body

increased body fat mass ( J:256504 )

• mice fed a Western diet exhibit a greater increase in body fat mass than controls on the same diet

increased susceptibility to diet-induced obesity ( J:256504 )

• mice fed a Western diet (high-fat with fructose in the drinking water) gain more weight than controls on the same diet, despite a progressive reduction in the caloric intake/body weight ratio

• Western diet-fed mice treated with antibiotic exhibit reduced weight gain

increased liver weight ( J:256504 )

• mice fed a Western diet show increased liver-to-body weight ratio

homeostasis/metabolism

decreased energy expenditure ( J:256504 )

• mice fed a Western diet show reduced total energy expenditure

increased susceptibility to diet-induced obesity ( J:256504 )

• mice fed a Western diet (high-fat with fructose in the drinking water) gain more weight than controls on the same diet, despite a progressive reduction in the caloric intake/body weight ratio

• Western diet-fed mice treated with antibiotic exhibit reduced weight gain

increased liver triglyceride level ( J:256504 )

• liver triglyceride levels are increased in mice fed a Western diet

• Western die-fed mice treated with antibiotic show decreased hepatic triglyceride accumulation

abnormal lipid metabolism ( J:256504 )

• mice fed a Western diet exhibit a higher hepatic lipid uptake

liver/biliary system

abnormal liver morphology ( J:256504 )

• mice fed a Western diet exhibit more severe liver injury than controls, showing increased expression of TLR4, TLR5, and TLR9, F4/80, MCP-1, and type I collagen

increased liver weight ( J:256504 )

• mice fed a Western diet show increased liver-to-body weight ratio

increased liver triglyceride level ( J:256504 )

• liver triglyceride levels are increased in mice fed a Western diet

• Western die-fed mice treated with antibiotic show decreased hepatic triglyceride accumulation

hepatic steatosis ( J:256504 )

• mice fed a Western diet show higher levels of micro and macrovesicular steatosis than controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
metabolic dysfunction-associated steatotic liver disease		DOID:0080208	OMIM:613282 OMIM:613387	J:256504