Phenotypes Associated with This Genotype

Genotype
MGI:6256822

• Allelic Composition: Col1a1^{tm1(CAG-EGFR*T790M*C797S*L858R)Mje}/Col1a1⁺
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:235747 )

• mice develop lung adenocarcinoma 8 weeks after adenoviral cre recombinase instillation and exhibit multi-focal tumors

• treatment together with the compound EAI045 (an allosteric tyrosine kinase inhibitor) and cetuximab induces marked tumor shrinkage

respiratory system

increased lung adenocarcinoma incidence ( J:235747 )

• mice develop lung adenocarcinoma 8 weeks after adenoviral cre recombinase instillation and exhibit multi-focal tumors

• treatment together with the compound EAI045 (an allosteric tyrosine kinase inhibitor) and cetuximab induces marked tumor shrinkage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:235747