Phenotypes Associated with This Genotype

Genotype
MGI:6256967

cx1

• Allelic Composition: Tg(Ins2-IGF1R)1Dh/0; Tg(RIP1-Tag)2Dh/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:205389 )

• mice die around 10 weeks of age

neoplasm

increased insulinoma incidence ( J:205389 )

• mice exhibit accelerated insulinoma progression compared to single Tg(RIP1-Tag)2Dh/0 mice

• mice treated with a small molecule tyrosine kinase inhibitor, AEW541 between 6 and 9 weeks of age results in a moderate, yet not significant, reduction in tumor volume, with no difference in proliferation rate of tumor cells but increased apoptosis rate

increased pancreatic islet cell carcinoma incidence ( J:205389 )

• mice exhibit enhanced tumor malignancy, with an almost complete absence of adenoma and a transition from hyperplastic/angiogenic islets to invasive carcinoma

• treatment with AEW541 fails to repress malignant tumor progression

endocrine/exocrine glands

increased insulinoma incidence ( J:205389 )

• mice exhibit accelerated insulinoma progression compared to single Tg(RIP1-Tag)2Dh/0 mice

• mice treated with a small molecule tyrosine kinase inhibitor, AEW541 between 6 and 9 weeks of age results in a moderate, yet not significant, reduction in tumor volume, with no difference in proliferation rate of tumor cells but increased apoptosis rate

increased pancreatic islet cell carcinoma incidence ( J:205389 )

• mice exhibit enhanced tumor malignancy, with an almost complete absence of adenoma and a transition from hyperplastic/angiogenic islets to invasive carcinoma

• treatment with AEW541 fails to repress malignant tumor progression