Phenotypes Associated with This Genotype

Genotype
MGI:6256982

• Allelic Composition: Rhbdf2^cub/Rhbdf2^cub
• Genetic Background: MRL.Cg-Rhbdf2^cub

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

enlarged sebaceous gland ( J:250259 )

alopecia ( J:250259 )

• mice show complete hair loss

abnormal hair follicle morphology ( J:250259 )

• follicular dystrophy

hyperkeratosis ( J:250259 )

skin hyperplasia ( J:250259 )

abnormal keratinocyte physiology ( J:250259 )

• mouse embryonic keratinocytes produce higher levels of amphiregulin after stimulation with phorbol-12-myristate-12-acetate

endocrine/exocrine glands

enlarged sebaceous gland ( J:250259 )

homeostasis/metabolism

enhanced wound healing ( J:250259 )

• Background Sensitivity: mice on a MRL/MpJ background exhibit accelerated wound healing in an ear punch assay compared to mice on the C57BL/6 background

cellular

abnormal fibroblast physiology ( J:250259 )

• mouse embryonic fibroblasts produce higher levels of amphiregulin after stimulation with phorbol-12-myristate-12-acetate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
palmoplantar keratoderma-esophageal carcinoma syndrome		DOID:0111506	OMIM:148500	J:250259