Phenotypes Associated with This Genotype

Genotype
MGI:6257845

• Allelic Composition: Tg(Alb-SND1)3aDsar/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:242582 )

• at 32 weeks after N-nitrosodiethylamine (DEN) injection, mice developaggressive hepatocellular carcinoma, with tumorigenesis affecting the entire liver, with elevated serum aspartate transaminase, alanine transaminase, and total protein levels compared to wild-type mice which have either no nodules or very small nodules

increased hepatocellular carcinoma incidence ( J:242582 )

• at 1 year of age, 42% of mice develop hepatic nodules that are hepatocellular carcinoma, with loss of hepatic architecture

• maker analysis indicates the expansion of tumor-initiation cells in livers

liver/biliary system

chronic liver inflammation ( J:242582 )

• mice exhibit chronic inflammation as indicated by increased expression of IL6 and TNFalpha and increased infiltration of macrophages in tumor bearing livers

increased hepatocellular carcinoma incidence ( J:242582 )

• at 1 year of age, 42% of mice develop hepatic nodules that are hepatocellular carcinoma, with loss of hepatic architecture

• maker analysis indicates the expansion of tumor-initiation cells in livers

abnormal hepatocyte physiology ( J:242582 )

• in a sphere formation assay, hepatocytes form robust spheres that gradually increase in size and number, indicating an expansion of tumor-initiation cells compared to wild-type hepatocytes which form small spheres

• hepatocytes show invasion through Matrigel that is not seen in wild-type hepatocytes

immune system

chronic liver inflammation ( J:242582 )

• mice exhibit chronic inflammation as indicated by increased expression of IL6 and TNFalpha and increased infiltration of macrophages in tumor bearing livers

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:242582 )

• at 32 weeks after N-nitrosodiethylamine (DEN) injection, mice developaggressive hepatocellular carcinoma, with tumorigenesis affecting the entire liver, with elevated serum aspartate transaminase, alanine transaminase, and total protein levels compared to wild-type mice which have either no nodules or very small nodules

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:242582