Phenotypes Associated with This Genotype

Genotype
MGI:6258417

cx44

• Allelic Composition: Dmd^mdx/Dmd^mdx; Selenos^tm1.1Sfa/Selenos⁺
• Genetic Background: involves: C57BL/6 * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased carbon dioxide production ( J:266872 )

• compared with Dmd^mdx homozygotes during the first two active hours at night

increased oxygen consumption ( J:266872 )

• compared with Dmd^mdx homozygotes during the first two active hours at night

abnormal respiratory quotient ( J:266872 )

• elevated as in Dmd^mdx homozygotes relative to wild-type mice

growth/size/body

decreased body mass index ( J:266872 )

• between 6 and 12 weeks compared with Dmd^mdx homozygotes

decreased lean body mass ( J:266872 )

• between 6 and 12 weeks compared with Dmd^mdx homozygotes

muscle

muscle phenotype ( J:266872 )

N • extensor digitalis longus and soleus muscles wet weight is normal

abnormal skeletal muscle fiber type ratio ( J:266872 )

• increased number of small fibres and fewer large fibres than in Dmd^mdx homozygotes

• however, there was no difference in the number of central nuclei suggesting normal regeneration