Phenotypes Associated with This Genotype

Genotype
MGI:6258421

cx2

• Allelic Composition: Terc^tm1Rdp/Terc^tm1Rdp; Tg(KRT5-Terf2)PMBlas/Y
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

focal hair loss ( J:102653 )

• double mutant mice exhibit more severe hair loss in light-exposed areas than age-matched single Tg(KRT5-Terf2)PMBlas mutant mice

dry skin ( J:102653 )

• double mutant mice exhibit more severe skin dryness in light-exposed areas than age-matched single Tg(KRT5-Terf2)PMBlas mutant mice

cellular

decreased telomere length ( J:102653 )

• double mutant mice exhibit significantly shorter telomeres in tail skin than either single Tg(KRT5-Terf2)PMBlas mutant mice or single Terc^tm1Rdp homozygotes