Phenotypes Associated with This Genotype

Genotype
MGI:6258423

cx1

• Allelic Composition: Ercc4^tm1Fwa/Ercc4^tm1Fwa; Tg(KRT5-Terf2)PMBlas/Y
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal telomere morphology ( J:102653 )

• double mutant mice show a significant rescue of telomere length in tail skin and of end-to-end fusions associated with critically short telomeres relative to single Tg(KRT5-Terf2)PMBlas mutant mice

• a significantly lower % of keratinocyte nuclei contain gamma-H2AX-positive foci in tail skin relative to single Tg(KRT5-Terf2)PMBlas mutant mice, indicating a partial rescue of DNA damage associated with short telomeres