Analysis Tools
pigmentation
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• male pups show a dramatic hypopigmentation of the hair coat
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• gray-haired skin shows normal melanocyte distribution but substantially less melanin in the hair follicles than control skin
• a reduction in melanin is noted in the hair bulb, where melanocytes form a conical cluster
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• a reduction in melanin is noted in the hair shaft
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• male pups develop uniformly gray coats; gray hair develops during the first period of hair production
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• melanocytes of gray-haired skin produce numerous, dakly-pigmented miniaturized melanosomes, indicating impaired melanosome growth with no significant reduction in melanosome number or pigment-making ability
• failure of melanosomes to grow leads to less production/accumulation of melanin per melanosome
• miniaturized melanosomes are still transferred to epithelial cells of the hair shaft but hair shafts receive less pigment in total, resulting in hypopigmentation and gray color
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integument
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• male pups show a dramatic hypopigmentation of the hair coat
|
|
|
• gray-haired skin shows normal melanocyte distribution but substantially less melanin in the hair follicles than control skin
• a reduction in melanin is noted in the hair bulb, where melanocytes form a conical cluster
|
|
|
• a reduction in melanin is noted in the hair shaft
|
|
|
• male pups develop uniformly gray coats; gray hair develops during the first period of hair production
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