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Phenotypes Associated with This Genotype
Genotype
MGI:6258771
Allelic
Composition
Grin1tm1Bhk/Grin1tm1Bhk
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Bhk mutation (2 available); any Grin1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a discrete T-maze paradigm with a 5-second delay, mice show reduced alternation indicating impaired spatial working memory
• about 25% of mice develop skin lesions caused by self-injurious, over-grooming behavior
• mice exhibit enhanced startle amplitudes, indicative of increased sensory-motor reactivity
• mice exhibit forepaw clasping/wringling behavior during tail suspension at a greater rate than controls
• activity patterns across the light-dark cycle indicate increased locomotor activity, which is more apparent during the light cycle
• in a mating paradigm, males initiate less social contact with an unfamiliar wild-type female than control males
• in a same-sex 3 chambered social approach/avoidance paradigm, males show reduced sociability compared to controls
• males emit fewer vocalizations during female social interaction than control males and the peak frequency of calls emitted is lower than in controls

hearing/vestibular/ear
• the phase-locked early auditory gamma-band response is reduced indicating deficits in neural synchrony
• mice show a 10-15% delay in the latency of the N1 component of the auditory-evoked response, however the amplitudes of P1 and N1 peaks are not different

nervous system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:203256


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory