Phenotypes for Cfap43 MGI:6258952 MGI Mouse

reproductive system

abnormal sperm flagellum morphology ( J:258613 )

• no normal sperm flagella are seen

• sperm flagella are distorted and contain excess cytoplasm

abnormal outer dense fiber morphology ( J:258613 )

• outer dense fibers of testicular spermatozoa are scattered and disordered

abnormal sperm axoneme morphology ( J:258613 )

• testicular spermatozoa lack the central pair of microtubules and the 9 peripheral microtubule doublets are disordered

absent sperm axonemal central pair ( J:258613 )

abnormal sperm flagellum thickness ( J:258613 )

• 4.5-8% of sperm show irregular flagella caliber

absent sperm flagellum ( J:258613 )

• 8-13.5% of sperm show absent flagella

coiled sperm flagellum ( J:258613 )

• 30.5-34.5% of sperm have coiled flagella

kinked sperm flagellum ( J:258613 )

• 4-8.5% of sperm show sperm angulation

short sperm flagellum ( J:258613 )

• 36-52.5% of sperm show short flagella

oligozoospermia ( J:258613 )

• sperm count is decreased

asthenozoospermia ( J:258613 )

• severe defects in sperm motility

abnormal cauda epididymis morphology ( J:258613 )

• cauda epididymides show shedding of residual bodies, abnormal cells, and disorganized spermatozoa with flagellar malformations

• however, spermatogonia and spermatocytes in seminiferous tubules have normal morphology

male infertility ( J:258613 )

• males are infertile

cellular