Phenotypes Associated with This Genotype

Genotype
MGI:6259179

• Allelic Composition: Tg(Eno2-Thrsp)#Cheo/0
• Genetic Background: C57BL/6-Tg(Eno2-Thrsp)#Cheo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased alertness ( J:266945 )

• in the Y-maze, mice show no differences in the total number of arm entries, however they exhibit a lower percentage of spontaneous alternation indicating impaired attention

• methylphenidate treated mice show increased spontaneous alternation in the Y-maze

• however, mice do not show locomotor alternation, impulsive behavior, anxiety, or motor-balance impairment

abnormal response to novel object ( J:266945 )

• in the novel-object recognition test, mice show a lower investigation time and discrimination index indicating impaired attention

• mice treated with methylphenidate show improved investigation time and enhanced discrimination index in the novel-object recognition test

nervous system

abnormal striatum morphology ( J:266945 )

• mice show elevated striatal dopaminergic-related gene expression that is normalized with methylphenidate treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:266945