About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6259414
cx1
Allelic
Composition		 Ay/a
Tg(tetO-Ppargc1a)1Dpk/0
Tg(Tyr-rtTA)37Lc/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (227 available); any a mutation (465 available)
Ay mutation (14 available); any a mutation (465 available)
Tg(tetO-Ppargc1a)1Dpk mutation (1 available)
Tg(Tyr-rtTA)37Lc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:194191 )
• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of Ay/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black
abnormal hair follicle melanogenesis ( J:194191 )
• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to Ay/a Tg(Tyr-rtTA)37Lc/0 mice

integument
darkened coat color ( J:194191 )
• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of Ay/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black
abnormal hair follicle melanogenesis ( J:194191 )
• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to Ay/a Tg(Tyr-rtTA)37Lc/0 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory