Phenotypes Associated with This Genotype

Genotype
MGI:6267296

• Allelic Composition: Far2^{tm2b(KOMP)Wtsi}/Far2^{tm2b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Far2^{tm2b(KOMP)Wtsi}/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

alopecia ( J:267002 )

• primary cicatricial alopecia

focal hair loss ( J:267002 )

• at 4 months on the ventral skin starting as gradual thinning of hair

• on the top of its head behind the ears

• however, hair shafts are normal

abnormal pilosebaceous unit morphology ( J:267002 )

• ectatic ducts leading to the surface of the mucocutaneous junction from Meibomian and clitoral glands unlike in control mice

abnormal sebocyte differentiation ( J:267002 )

• sebocytes fail to fully disintegrate in the sebaceous gland and form clustered eosinophilic remnants in the infundibula

small sebaceous gland ( J:267002 )

• in the skin

abnormal hair follicle morphology ( J:267002 )

• older mice exhibit follicular dystrophy associated with inflammatory cells unlike in control mice

• follicular scars extend below sebaceous glands in the dermis unlike in control mice

abnormal skin morphology ( J:267002 )

• altered skin surface lipids (lower wax monoesters, unsaturated fatty acids and glycerophosphocholines but higher saturated fatty acids, triacylglycerols, ceramides and (lyso)phosphocholines

abnormal skin sebaceous gland morphology ( J:267002 )

• very few clear cytoplasmic vacuoles instead containing irregular material

• with swollen mitochondria

homeostasis/metabolism

abnormal lipid level ( J:267002 )

• altered skin surface lipids (lower wax monoesters, unsaturated fatty acids and glycerophosphocholines but higher saturated fatty acids, triacylglycerols, ceramides and (lyso)phosphocholines

endocrine/exocrine glands

abnormal sebocyte differentiation ( J:267002 )

• sebocytes fail to fully disintegrate in the sebaceous gland and form clustered eosinophilic remnants in the infundibula

abnormal skin sebaceous gland morphology ( J:267002 )

• very few clear cytoplasmic vacuoles instead containing irregular material

• with swollen mitochondria

small sebaceous gland ( J:267002 )

• in the skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alopecia		DOID:987	OMIM:PS203655	J:267002