Phenotypes Associated with This Genotype

Genotype
MGI:6267415

cn8

• Allelic Composition: Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺; Tg(CAG-lacZ,-Miox)#Ysk/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased renal tubule apoptosis ( J:266834 )

• induced by cisplatin

homeostasis/metabolism

increased circulating creatinine level ( J:266834 )

• induced by cisplatin

increased blood urea nitrogen level ( J:266834 )

• induced by cisplatin

increased susceptibility to injury ( J:266834 )

• mice exhibit worsened cisplatin-induced acute kidney injury with increased weight loss, serum creatinine and urea levels, and fulminant apoptosis of renal tubular cells, and accentuated cytolysis of tubular cells with loss of brush border and reactive oxygen species generation compared with wild-type mice

cellular

increased renal tubule apoptosis ( J:266834 )

• induced by cisplatin

oxidative stress ( J:266834 )

• induced by cisplatin