Phenotypes Associated with This Genotype

Genotype
MGI:6269453

• Allelic Composition: Npr3^kylb/Npr3^kylb
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body length ( J:243806 )

• at 12 weeks of age crown to rump length is increased by ~12% compared to littermate controls

skeleton

increased width of hypertrophic chondrocyte zone ( J:243806 )

• at P1

increased length of long bones ( J:243806 )

kyphosis ( J:243806 )

• thoraco-lumbar kyphosis

abnormal vertebrae morphology ( J:243806 )

• hypertrophic zone is expanded ~2-fold and the central region consists mostly of cartilage in mice at P1

abnormal vertebral epiphyseal plate morphology ( J:243806 )

• hypertrophic zone is expanded ~2-fold in mice at P1

elongated vertebral body ( J:243806 )

• increased vertebrae length

abnormal bone structure ( J:243806 )

• ~22% and ~12% increase in bone area in females and males, respectively

increased bone mineral content ( J:243806 )

• ~18% increase in females

delayed endochondral bone ossification ( J:243806 )

• the central region of vertebrae consists mostly of cartilage in mice at P1

• decrease in formation of bone matrix in long bones and vertebrae at P1

adipose tissue

decreased total body fat amount ( J:243806 )

♀ • ~28% decrease in percentage body fat in females

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:243806 )

♀ • in females but not males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bone disease		DOID:0080001		J:243806