mortality/aging
• nearly all mice die within hours of birth with few surviving to weaning
|
skeleton
• at E14.75 with shortened primary centers of ossification
|
short radius
(
J:228857
)
• at E14.75 with shortened primary centers of ossification
|
short ulna
(
J:228857
)
• at E14.75 with shortened primary centers of ossification
|
• at E14.75 with shortened primary centers of ossification
|
• reduced recruitment of blood vessels into the cartilage plate of the radii and ulnae at E15.5
|
• reduced matrix mineralization in the radii at P1
• of the cranium at E16.5, P2 and P5
|
• reduced cranium mineralization at E16.5, P2 and P5
|
growth/size/body
limbs/digits/tail
• contracture
|
• at E14.75 with shortened primary centers of ossification
|
short radius
(
J:228857
)
• at E14.75 with shortened primary centers of ossification
|
short ulna
(
J:228857
)
• at E14.75 with shortened primary centers of ossification
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
distal arthrogryposis | DOID:0050646 |
OMIM:PS108120 |
J:228857 |