Phenotypes Associated with This Genotype

Genotype
MGI:6272036

• Allelic Composition: Tnf^Bpsm1/Tnf^Bpsm1
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb paralysis ( J:226052 )

• mice become paralyzed around 6 weeks of age

cardiovascular system

aortic aneurysm ( J:226052 )

• Background Sensitivity: aortic aneurism is much less pronounced on the C57BL/6 background than in mice on a BALB/c background

aortic valve inflammation ( J:226052 )

mitral valve inflammation ( J:226052 )

craniofacial

accelerated temporomandibular joint osteoarthritis ( J:226052 )

• temporomandibular joints are severely affected

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:226052 )

immune system

aortic valve inflammation ( J:226052 )

mitral valve inflammation ( J:226052 )

accelerated temporomandibular joint osteoarthritis ( J:226052 )

• temporomandibular joints are severely affected

increased circulating tumor necrosis factor level ( J:226052 )

rheumatoid arthritis ( J:226052 )

• mice develop polyarthritis at an accelerated rate compared to heterozygotes

• polyarthritis is due to abnormal proliferation of synoviocytes and high mechanical stress

limbs/digits/tail

abnormal wrist joint morphology ( J:226052 )

• 3 week old mice exhibit clubbed wrists

mortality/aging

mortality/aging ( J:226052 )

N • Background Sensitivity: no mice on the C57BL/6 background die up to 200 days of age while sudden death is seen on the BALB/c background

skeleton

accelerated temporomandibular joint osteoarthritis ( J:226052 )

• temporomandibular joints are severely affected

rheumatoid arthritis ( J:226052 )

• mice develop polyarthritis at an accelerated rate compared to heterozygotes

• polyarthritis is due to abnormal proliferation of synoviocytes and high mechanical stress

abnormal wrist joint morphology ( J:226052 )

• 3 week old mice exhibit clubbed wrists

joint dislocation ( J:226052 )

• 3 week old mice exhibit luxated ankles

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
rheumatoid arthritis		DOID:7148	OMIM:180300	J:226052