Phenotypes Associated with This Genotype

Genotype
MGI:6272038

• Allelic Composition: Tnf^Bpsm1/Tnf⁺
• Genetic Background: C.Cg-Tnf^Bpsm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

aortic aneurysm ( J:226052 )

• Background Sensitivity: all mice exhibit aortic root aneurisms; aneurisms are much more pronounced on the BALB/c background than on a C57BL/6 background

thick mitral valve ( J:226052 )

thick aortic valve ( J:226052 )

cardiac fibrosis ( J:226052 )

• fibrosis involving the aortic and mitral valves

cardiac valve regurgitation ( J:226052 )

• valve disease manifests mainly as regurgitation, indicated by the presence of a backward aortic blood flow

cardiovalvulitis ( J:226052 )

• aortic and mitral valve inflammation

• however, the tricuspid and pulmonary valves are unaffected

aortic valve inflammation ( J:226052 )

mitral valve inflammation ( J:226052 )

immune system

cardiovalvulitis ( J:226052 )

• aortic and mitral valve inflammation

• however, the tricuspid and pulmonary valves are unaffected

aortic valve inflammation ( J:226052 )

mitral valve inflammation ( J:226052 )

mortality/aging

premature death ( J:226052 )

• Background Sensitivity: many mice die suddenly between 90 and 160 days of age on the BALB/c background unlike on a C57BL/6 background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
heart valve disease		DOID:4079		J:226052