Analysis Tools
embryo
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• overall, melanoblasts exhibit a much lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E14.5) relative to wild-type controls
• however, no differences in apoptosis, cell differentiation or fate are observed
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• in the trunk region, melanoblast number is normal at E10.5 but significantly lower than that in wild-type controls at each developmental stage from E12.5 to E15.5; this difference increases with time
• at E14.5, melanoblasts are less abundant than in mice hemizygous for the Tg(Tyr-Ctnnb1/EGFP)#Lru transgene, reflecting the differences in coat color observed after birth
• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis
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cellular
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• overall, melanoblasts exhibit a much lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E14.5) relative to wild-type controls
• however, no differences in apoptosis, cell differentiation or fate are observed
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nervous system
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• in the trunk region, melanoblast number is normal at E10.5 but significantly lower than that in wild-type controls at each developmental stage from E12.5 to E15.5; this difference increases with time
• at E14.5, melanoblasts are less abundant than in mice hemizygous for the Tg(Tyr-Ctnnb1/EGFP)#Lru transgene, reflecting the differences in coat color observed after birth
• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis
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