Phenotypes Associated with This Genotype

Genotype
MGI:6272838

• Allelic Composition: Pgrmc1^em1Ejho/Pgrmc1^em1Ejho
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased white fat cell lipid droplet size ( J:268130 )

• lipid droplets in livers of high-fat fed mice are larger compared to controls

homeostasis/metabolism

increased circulating free fatty acids level ( J:268130 )

• high-fat fed and normal-diet fed mice show an increase in serum free fatty acid levels compared to respective controls

decreased circulating triglyceride level ( J:268130 )

• high-fat fed mice show a slight decrease in serum triglyceride levels

• mice fed a normal diet show a decrease in serum triglyceride levels

increased circulating alanine transaminase level ( J:268130 )

• normal diet and high-fat fed mice show higher (1.29-fold and 1.26-fold, respectively) serum levels of alanine transaminase

increased liver triglyceride level ( J:268130 )

• high-fat fed mice show increased liver triglyceride levels

immune system

liver inflammation ( J:268130 )

• high-fat fed mice show increased macrophage (F4/80+) infiltration in the liver indicating that mutants are more prone to non-alcoholic fatty liver-induced liver inflammation

liver/biliary system

increased liver triglyceride level ( J:268130 )

• high-fat fed mice show increased liver triglyceride levels

liver inflammation ( J:268130 )

• high-fat fed mice show increased macrophage (F4/80+) infiltration in the liver indicating that mutants are more prone to non-alcoholic fatty liver-induced liver inflammation

hepatic steatosis ( J:268130 )

• high-fat fed mice show increased lipid accumulation within the liver compared to controls fed the same diet indicating that mutants are more prone to non-alcoholic steatohepatitis

liver fibrosis ( J:268130 )

• high-fat fed mice show increased hepatic fibrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
metabolic dysfunction-associated steatotic liver disease		DOID:0080208	OMIM:613282 OMIM:613387	J:268130