behavior/neurological
• P10-P12 mice show a reduction in motor coordination on the rotarod, however this defect is no longer present in adult P28 mice
• P10-P12 mice show a higher number of errors on the grid walking test, however this defect is no longer present in adult P28 mice
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nervous system
• mice show an increase of bundles of unsorted mixed caliber axons in nerves at P11 that are not seen in wild-type nerves, however by P14, the radial sorting defect is no longer visible, indicating a delay in myelination
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• P28 sciatic nerves show a mild hypomyelination
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
neuropathy | DOID:870 | J:267903 |