Phenotypes Associated with This Genotype

Genotype
MGI:6273511

• Allelic Composition: Kras^tm5Tyj/Kras⁺; Pdx1^{tm1.1(flpo)Most}/Pdx1⁺; Trp53^tm1.1Dgk/Trp53⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 4.5 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550