Phenotypes Associated with This Genotype

Genotype
MGI:6273518

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Tg(Flt3-cre)#Ccb/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:247853 )

• mice die at a median age of 26 days

growth/size/body

weight loss ( J:247853 )

• mice show progressive weight loss after 2 weeks of age

hepatosplenomegaly ( J:247853 )

• mice show hepatosplenomegaly after 2 weeks of age

endocrine/exocrine glands

thymus atrophy ( J:247853 )

• mice exhibit an atrophied thymus

hematopoietic system

thymus atrophy ( J:247853 )

• mice exhibit an atrophied thymus

hepatosplenomegaly ( J:247853 )

• mice show hepatosplenomegaly after 2 weeks of age

anemia ( J:247853 )

• mice show anemia after 2 weeks of age

thrombocytopenia ( J:247853 )

• mice show thrombocytopenia after 2 weeks of age

increased dendritic cell number ( J:247853 )

• mice show an increase in the frequency of CD11c+dendritic cells in the bone marrow and spleen, with expansion particularly in the atrophied thymus

• mice show histiocytic infiltrate in the spleen, liver, lung and intestines and an increase in frequency of CD11b+Gr1+ cells in the blood, bone marrow, liver, and spleen

decreased B cell number ( J:247853 )

• frequency of B220+ B lymphocytes is decreased

decreased T cell number ( J:247853 )

• frequency of CD3+ T lymphocytes is decreased

decreased double-negative T cell number ( J:247853 )

• atrophied thymus shows a deficit of CD4-CD8-CD25+ committed T cell progenitors

decreased double-positive T cell number ( J:247853 )

• atrophied thymus shows a deficit of CD4+CD8+ double-positive cells

increased leukocyte cell number ( J:247853 )

• mice show leukocytosis after 2 weeks of age

increased monocyte cell number ( J:247853 )

• mice show monocytosis after 2 weeks of age

decreased hematopoietic stem cell number ( J:247853 )

• moribund mice show a reduction hematopoietic stem cells (LSK CD150+CD48-) and multipotent progenitors (LSK CD150-CD48+) in the bone marrow and spleen

immune system

thymus atrophy ( J:247853 )

• mice exhibit an atrophied thymus

hepatosplenomegaly ( J:247853 )

• mice show hepatosplenomegaly after 2 weeks of age

increased dendritic cell number ( J:247853 )

• mice show an increase in the frequency of CD11c+dendritic cells in the bone marrow and spleen, with expansion particularly in the atrophied thymus

• mice show histiocytic infiltrate in the spleen, liver, lung and intestines and an increase in frequency of CD11b+Gr1+ cells in the blood, bone marrow, liver, and spleen

decreased B cell number ( J:247853 )

• frequency of B220+ B lymphocytes is decreased

decreased T cell number ( J:247853 )

• frequency of CD3+ T lymphocytes is decreased

decreased double-negative T cell number ( J:247853 )

• atrophied thymus shows a deficit of CD4-CD8-CD25+ committed T cell progenitors

decreased double-positive T cell number ( J:247853 )

• atrophied thymus shows a deficit of CD4+CD8+ double-positive cells

increased leukocyte cell number ( J:247853 )

• mice show leukocytosis after 2 weeks of age

increased monocyte cell number ( J:247853 )

• mice show monocytosis after 2 weeks of age

neoplasm

increased leukemia incidence ( J:247853 )

• mice develop a juvenile myelomonocytic leukemia-like disease

liver/biliary system

hepatosplenomegaly ( J:247853 )

• mice show hepatosplenomegaly after 2 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
juvenile myelomonocytic leukemia		DOID:0050458	OMIM:607785	J:247853