Analysis Tools
growth/size/body
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• fat mass is increased in 20 week old mice
• however, lean mass is normal
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• males and females are 4.1-7.5% and 6-14.3% heavier than wild-type mice, respectively, from 7 weeks of age
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homeostasis/metabolism
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• mice exhibit lower core body temperature during acute cold stress at 20 weeks of age
• however, mice exhibit normal energy expenditure and normal food intake and activity levels
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• males and females exhibit elevated fasting blood glucose at 20 weeks of age
• fasting blood glucose levels are elevated only in females at 5 weeks of age
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• fasting plasma amylin levels are elevated in males prior to obesity; amylin levels are still elevated at 20 weeks of age
• however, fasting plasma glucagon and gastric inhibitory polypeptide levels are normal
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• fasting plasma ghrelin levels are lower in males prior to obesity
• however, ghrelin levels are similar to wild-type at 20 weeks of age
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• follicle stimulating hormone levels are lower in obese males at 20 weeks of age
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• luteinizing hormone levels are lower in obese males at 20 weeks of age
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• mice exhibit elevated fasting plasma insulin levels at 5 and 20 weeks of age
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• mice exhibit higher fasting plasma leptin levels at 20 weeks of age
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• fasting plasma peptide YY (PYY) are elevated in males prior to obesity
• however, PYY levels are similar to wild-type at 20 weeks of age
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• thyroid stimulating hormone levels are lower in obese males at 20 weeks of age
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• fasting plasma resistin levels are elevated only in males at 20 weeks of age
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• non-esterified fatty acids are lower in females at 5 weeks of age
• however, levels of non-esterified fatty acids are similar to wild-type levels at 20 weeks of age
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• females exhibit elevated phospholipid levels at 5 weeks of age and both males and females exhibit higher phospholipid levels at 20 weeks of age
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• mice exhibit elevated C-peptide levels at 20 weeks of age
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• mice exhibit glucose intolerance at 20 weeks of age
• however, insulin sensitivity is similar to wild-type mice at 20 weeks of age
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• growth hormone levels are lower in obese males at 20 weeks of age
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• prolactin levels are lower in obese males at 20 weeks of age
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• mice exhibit higher cholesterol levels at 20 weeks of age
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• mice exhibit higher triglyceride levels at 20 weeks of age
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adipose tissue
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• mice exhibit greater brown adipose tissue percentage at 20 weeks of age, but not at 5 weeks
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• white adipose tissue percent is increased
(J:201055)
• mice exhibit greater gonadal white adipose tissue and inguinal white adipose tissue percentage at 20 weeks of age, but not at 5 weeks
(J:256501)
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• fat mass is increased in 20 week old mice
• however, lean mass is normal
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• adipocytes are 50% larger in gonadal white adipose tissue and 27% larger in inguinal white adipose tissue depots
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| abdominal obesity-metabolic syndrome | DOID:0060611 |
OMIM:PS605552 |
J:256501 | |
| obesity | DOID:9970 |
OMIM:601665 |
J:256501 | |
