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Phenotypes Associated with This Genotype
Genotype
MGI:6274280
Allelic
Composition
Tg(Krt14-Rac1*G12V)#Mrnk/0
Genetic
Background
involves: CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

integument
• lesions show hemorrhage (Auspitz sign) following scale removal
• skin shows mixed inflammatory infiltrates
• lesional skin shows increased CD4+ and CD8+ lymphocytes, neutrophils, and dendritic cells
• stratum corneum shows increased CD3+ lymphocytes expressing IL17 and ROR-gamma and CD68+ cells, indicating Munros microabscesses
• nail changes range from ridging to marked thickening and onycholysis
• mice show mild to severe nail changes, with nail matrix showing psoriasiform hyperplasia
• skin shows psoriasiform hyperplasia, hypogranulosis, mixed inflammatory infiltrates, dilated vessels in dermal papillae and parakeratosis
• however, mucosa does not exhibit proliferative or inflammatory changes
• by 1 month of age, most mice develop edema of the tail and paws
• suprabasilar proliferation
• by 1 month of age, most mice develop erythema of the tail and paws
• mice develop erythematous, scaly skin lesions by day 7, that thicken by day 14 and are localized to ears, paws, tail and snout
• mutant pups develop psoriasis-like lesions in response to trauma created by mutant mothers biting the pups whiskers and snout hair
• mice typically exhibit wound-induced psoriasiform hyperplasia after tail snipping
• topical corticosteroid treatment improves skin lesions
• cyclosporin A treatment reduces epidermal thickness, proliferation and T cell infiltration

behavior/neurological
• mutant mothers often bite their pups whiskers and snout hair, possibly to decrease nursing-related itching

cardiovascular system
• lesions show hemorrhage (Auspitz sign) following scale removal

homeostasis/metabolism
• 3 week old mice show a 7-fold and 2.5-fold increases in psoriasis-associated cytokine IL-22 and IL-23 in sera
• by 1 month of age, most mice develop edema of the tail and paws

immune system
• 3 week old mice show a 7-fold and 2.5-fold increases in psoriasis-associated cytokine IL-22 and IL-23 in sera
• mutants with joint involvement show neutrophilic infiltrates near joint spaces
• skin shows mixed inflammatory infiltrates
• lesional skin shows increased CD4+ and CD8+ lymphocytes, neutrophils, and dendritic cells
• stratum corneum shows increased CD3+ lymphocytes expressing IL17 and ROR-gamma and CD68+ cells, indicating Munros microabscesses

skeleton
• mutants with joint involvement show neutrophilic infiltrates near joint spaces
• about 50% of mice show a mutilating arthropathy, with bony paw deformations and/or partial tail autoamputation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
psoriasis DOID:8893 OMIM:PS177900
J:237134


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory