Phenotypes Associated with This Genotype

Genotype
MGI:6275022

tg1

• Allelic Composition: Tg(Myh6-Kcnj11*)1Wco/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:116284 )

• mice exhibit increased mortality after 16 weeks of age

cardiovascular system

abnormal impulse conducting system conduction ( J:116284 )

• ventricular effective refractory period is prolonged

• however, mice do not exhibit conduction abnormalities, with normal sinus rhythm activation patterns and conduction velocities in pacing experiments

decreased QRS amplitude ( J:116284 )

• QRS amplitude is decreased

• however, hemodynamic parameters, including left ventricular end-diastolic pressure, +dP/dt, -dP/dt, and the relaxation constant Tau are unchanged, indicating unchanged ventricular function

abnormal myocardial fiber physiology ( J:116284 )

• action potential duration in cardiac myocytes under current-clamp conditions are prolonged and isoproterenol leads to action potential prolongation with some myocytes developing early afterdepolarizations

abnormal myocardial fiber currents ( J:116284 )

• ventricular myocytes exhibit smaller current density at 0 mV and dinitrophenol, pinacidil or bimakalim fail to activate sarcolemmal ATP-sensitive K+ channels in cardiac myocytes indicating that mice lack sarcolemmal ATP-sensitive K+ channels