Phenotypes Associated with This Genotype

Genotype
MGI:6275174

• Allelic Composition: Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺; Pten^tm2.1Ppp/Pten⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:239660 )

♂ • 1 of 5 mice older than 12 months exhibit areas of invasive prostate carcinoma

increased prostate intraepithelial neoplasia incidence ( J:239660 )

♂ • mice exhibit a high penetrance of focal areas of high-grade prostatic intraepithelial neoplasia by 6 months of age, characterized by nuclear atypia

neoplasm

increased prostate gland adenocarcinoma incidence ( J:239660 )

♂ • 1 of 5 mice older than 12 months exhibit areas of invasive prostate carcinoma

increased prostate intraepithelial neoplasia incidence ( J:239660 )

♂ • mice exhibit a high penetrance of focal areas of high-grade prostatic intraepithelial neoplasia by 6 months of age, characterized by nuclear atypia

reproductive system

increased prostate gland adenocarcinoma incidence ( J:239660 )

♂ • 1 of 5 mice older than 12 months exhibit areas of invasive prostate carcinoma

increased prostate intraepithelial neoplasia incidence ( J:239660 )

♂ • mice exhibit a high penetrance of focal areas of high-grade prostatic intraepithelial neoplasia by 6 months of age, characterized by nuclear atypia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:239660