Analysis Tools
growth/size/body
weight loss
(
J:101255
)
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• mice begin to progressively lose weight after 2 weeks of continuous doxycycline treatment and lose on average 15% of preinduction weight following 6 weeks of doxycycline; females tend to lose more weight than males
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homeostasis/metabolism
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• hydroxyproline content in lung is increased over 70% in doxycyline treated mice
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respiratory system
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• enlarged distal air spaces are detected adjacent to areas of severe adventitial, peribronchial, or pleural fibrosis
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• mice develop progressive pulmonary fibrosis following doxycycline treatment, initially developing in the perivascular adventitia, peribronchial, and pleural regions but later extending into the interstitium
• fibrotic regions are composed of increased collagen, extracellular matrix, and cellular proliferation
• however, inflammatory cell infiltration is not seen in the fibrotic regions
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