Phenotypes Associated with This Genotype

Genotype
MGI:6275557

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-TGFA)22.1Kor/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased hydroxyproline level ( J:240947 )

• hydroxyproline content is increased in the lungs of doxycycline treated mice

respiratory system

pulmonary fibrosis ( J:240947 )

• mice develop progressive pulmonary fibrosis in in the pleural and perivascular adventitia regions following doxycycline treatment

• however, 4 weeks after ending doxycycline treatment, fibrosis partially resolves

pulmonary interstitial fibrosis ( J:240947 )

• doxycycline treated mice show fibrosis extending from the subpleural and adventitial regions into the interstitium; these lesions grow in both number and volume throughout 7 weeks of doxycycline treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary fibrosis		DOID:3770		J:240947