Phenotypes Associated with This Genotype

Genotype
MGI:6275604

• Allelic Composition: Cic^{tm1c(KOMP)Wtsi}/Cic^{tm1c(KOMP)Wtsi}; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:240674 )

• in a fear conditioning assay, mice exhibit reduced freezing, especially in the test of spatial context, indicating impaired learning and memory

• however, mice show normal social behavior in the three-chamber test

decreased anxiety-related response ( J:240674 )

• in the elevated plus-maze test, mice spend more time in the open arm and less in the closed arm, indicating reduced anxiety

increased locomotor activity ( J:240674 )

• mice cover a greater distance at a greater speed in the open-field test

• mice treated with a low dose of amphetamine show reduced hyperactivity

nervous system

decreased dentate gyrus size ( J:240674 )

• the hippocampal dentate gyrus shows decreased thickness at 20 weeks of age, however the CA1 and CA3 regions are normal

abnormal cerebral cortex morphology ( J:240674 )

• mice exhibit a transient increase of apoptosis in the upper layers of the cortex at P5 that is no longer seen at P10

• however, the corpus callosum appears normal

decreased cerebral cortex cell number ( J:240674 )

• the number of CUX1+ neurons in layers 2-4 is reduced at 5 weeks

• numbers of CUX1+ and SATB2+ neurons in layers 2-4 of the cortex are normal at P0 but decline postnatally and by P10 are comparable to that at 5 weeks

• the numbers of progenitors and their proliferation rates in embryonic cortex are not different from wild-type

thin cerebral cortex ( J:240674 )

• mice show reduced thickness of cortical layers 2-4 at 5 and 20 weeks of age, whereas thickness of layers 5 and 6 remains normal

abnormal pyramidal neuron dendrite morphology ( J:240674 )

• layer 2/3 pyramidal neurons show reduced dendritic branching complexity in 5 week old mice

• however, layer 5 pyramidal neurons show normal dendritic branching

decreased neurotransmitter release ( J:240674 )

• mice show a decrease in the probability of presynaptic neurotransmitter release

• however, basal synaptic transmission and long-term synaptic plasticity are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
disease of mental health		DOID:150		J:240674