Phenotypes for Pik3r1 MGI:6275834 MGI Mouse

decreased subcutaneous adipose tissue amount ( J:234657 )

• mice show a reduction in subcutaneous adipose tissue mass at 12 weeks of age

• mice show a decrease in subcutaneous adipose tissue at 9 months of age, with an overall decrease in adipose tissue mass and a higher frequency of small adipocytes in this depot

• however, no change in interscapular brown adipose tissue mass or lean mass is seen

decreased white fat cell size ( J:234657 )

• decrease in average adipocyte size in subcutaneous adipose tissue

• subcutaneous adipose tissue shows a change in adipocyte size distribution, with a higher frequency of smaller adipocytes

• however, the percentage of adipose tissue progenitor cells isolated from the stromovascular fraction of epididymal and subcutaneous adipose tissue does not differ

abnormal epididymal fat pad morphology ( J:234657 )

• mice show a decrease in epididymal adipose tissue at 9 months of age, with an overall decrease in adipose tissue mass and a higher frequency of small adipocytes in this depot

lipodystrophy ( J:234657 )

• mice exhibit partial lipodystrophy

decreased adipocyte glucose uptake ( J:234657 )

• white adipose tissue shows an impairment in glucose uptake

• howeover, no difference in skeletal muscle and brown adipose tissue glucose uptake is seen

pancreatic islet hyperplasia ( J:234657 )

• by 12 weeks of age, islets are larger and a 47% increase in islet area is seen

decreased insulin secretion ( J:234657 )

• secretion of insulin from islets is defective; mutant islets do not show an increase in insulin levels 2 minutes after glucose administration as is seen in controls

• islets do not exhibit an increase in insulin secretion when transitioned from low to high glucose as in control islets

decreased body size ( J:234657 )

decreased body weight ( J:234657 )

• both males and females have decreases in body weight over the first 3 months, with this difference persisting at 6 months

• males weigh 12.8% less than controls at 6 months of age

• however, food and water consumption are unchanged when adjusted for body weight

decreased body length ( J:234657 )

• body length is decreased at 12 weeks of age

decreased insulin secretion ( J:234657 )

• secretion of insulin from islets is defective; mutant islets do not show an increase in insulin levels 2 minutes after glucose administration as is seen in controls

• islets do not exhibit an increase in insulin secretion when transitioned from low to high glucose as in control islets

hyperglycemia ( J:234657 )

• fed males exhibit hyperglycemia

increased circulating insulin level ( J:234657 )

• fed serum insulin levels are elevated in females

• both fasted and fed insulin levels are elevated in males

• however, liver histology, circulating free fatty acids, and triglycerides are unaltered and oxygen consumption, carbon dioxide production, and respiratory exchange ratio are normal

increased circulating insulin-like growth factor I level ( J:234657 )

• mice show a modest, but significant, elevation in serum IGF-1 levels

impaired glucose tolerance ( J:234657 )

• both males and females show an elevation of glucose levels during an intraperitoneal glucose tolerance test

insulin resistance ( J:234657 )

• both males and females show no decrease in blood glucose during an insulin tolerance test indicating insulin resistance

• euglycemic-hyperinsulinemic clamps show a marked insulin resistance in males, with a 58% reduction in glucose infusion rate and a concomitant decrease in the rate of glucose turnover

• hepatic glucose production is only suppressed by 76% compared to 100% in controls in response to insulin