Phenotypes Associated with This Genotype

Genotype
MGI:6276671

• Allelic Composition: Tg(Mpz)88.4Mfel/0
• Genetic Background: FVB/N-Tg(Mpz)88.4Mfel

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:77658 )

muscle

muscle weakness ( J:77658 )

• mice exhibit variable signs of muscle weakness such as clenching of the apws, dragging of hind limbs and floppy tail

• symptoms are least severe in this line

nervous system

abnormal myelin sheath morphology ( J:77658 )

• sciatic nerves show uncompaction of the myelin sheath

tomacula ( J:77658 )

• sciatic nerves show tomacula

dysmyelination ( J:77658 )

• sciatic nerves show hypomyelination

decreased nerve conduction velocity ( J:77658 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease type 1B		DOID:0110152	OMIM:118200	J:77658