Phenotypes Associated with This Genotype

Genotype
MGI:6277933

• Allelic Composition: Lama3^tm1Arte/Lama3^tm1Arte; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:240054 )

• mice fed a tamoxifen-containing diet are slightly smaller after 10-11 weeks on tamoxifen

integument

skin inflammation ( J:240054 )

• blisters of tamoxifen-treated mice are associated with an inflammatory reaction in the dermis, with accumulation of myofibroblasts, granulocytes and macrophages in the repair tissue filling the blisters and accumulating below blisters

• blister cavities are filled with eosinophil-rich material in some areas

abnormal nail morphology ( J:240054 )

• mice are losing their nails after 10-11 weeks of tamoxifen treatment and most nails are lost after 15-16 weeks of tamoxifen

abnormal hair follicle orientation ( J:240054 )

• hair follicles tend to be perpendicular to the skin surface in tamoxifen-treated mice rather than the oblique/tilted orientation seen in controls

dermal-epidermal separation ( J:240054 )

• skin shows sporadic detachment between epidermis and dermis starting not earlier than 8 weeks after beginning tamoxifen treatment and blisters are present in back skin of all mice after 10-15 weeks, with extensive detachment of the entire interfollicular epidermis from the dermis and increased dermal cellularity

bleb ( J:240054 )

• tamoxifen-treated mice have bullae on the footpads

blistering ( J:240054 )

• mice start to develop blisters and erosions on the footpads around 10-11 weeks after the onset of tamoxifen-containing diet and exhibit scabs under the paws after 15-16 weeks of tamoxifen

• mice show blister formation below the interfollicular epidermis following tamoxifen treatment

thick skin ( J:240054 )

• integument is thicker in tamoxifen-treated mice

skin fibrosis ( J:240054 )

• blisters are associated with an accumulation of fibrillar collagens in tamoxifen-treated mice indicating skin fibrosis

homeostasis/metabolism

increased collagen level ( J:240054 )

• tamoxifen-treated mice show accumulation of collagen in the dermis

immune system

skin inflammation ( J:240054 )

• blisters of tamoxifen-treated mice are associated with an inflammatory reaction in the dermis, with accumulation of myofibroblasts, granulocytes and macrophages in the repair tissue filling the blisters and accumulating below blisters

• blister cavities are filled with eosinophil-rich material in some areas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
junctional epidermolysis bullosa		DOID:3209		J:240054